Gabapentin — The Popular but Controversial Anticonvulsant Drug May Be Zeroing in on the Pathophysiology of Disease

Originally marketed under the brand name Neurontin, anticonvulsant drug gabapentin has become one of most widely prescribed—and controversial—drugs in America. On market for nearly three decades, been prescribed everything from chronic cough to pain and hot flashes bipolar disorder; but is it real deal, or just brain-child aggressive marketing, false advertising, wishful thinking? This critical review will dissect down its molecular roots trace wide-ranging effects better understand persons who use it. It also discuss how (and other drugs) may be doing something more profound than treating acute symptoms. An emerging hypothesis contends that psychiatric related function symptoms are driven by pathological hyperactivity symptom-related circuits brain same abnormality may, over time, driving development a plethora general medical conditions, including diabetes, high blood pressure, cardiovascular disease, autoimmune diseases, dementia, cancer. Emerging evidence suggests underlying physiological abnormality—an inherent hyperexcitability neurological system—is very common, clinical correlation inherited classic autosomal dominant distribution. There reflected one’s resting vital signs, an observation could help carriers identify trait themselves. Gabapentin, together with pharmacological non-pharmacological) interventions reduce neuronal excitability, addition their immediate effects, have potential prevent long-term erosive simply turning stress response. Recognition this usher history’s greatest campaign fight against sickness disease.